Author

Kyle S. Hoffman

Bioinformatics Solutions (Canada)ORCID 0000-0003-0170-2090Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Abdessamad Youssfi AlaouiiD· 1 shared Alexa Marie BarrosoiD· 1 shared Alexandra Marie CarboneiD· 1 shared Alicia Bilbao MartineziD· 1 shared Austin Daniel NewsamiD· 1 shared Baozhen ShaniD· 1 shared Daniel BilbaoiD· 1 shared Dhanvantri ChahariD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

Abdessamad Youssfi AlaouiORCID

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2 papers

Recent·Most cited

Cancer BiologyCancer ResearchPeer-reviewedJul 31, 2025

NRF2 translation block by inhibition of cap-dependent initiation sensitizes lymphoma cells to ferroptosis and CAR-T immunotherapy

Paola Manara, Austin Daniel Newsam, Venu Venkatarame Gowda Saralamma…·Jonathan Harry Schatz

This study shows that inhibiting cap-dependent translation in lymphoma cells increases sensitivity to ferroptosis and CAR-T therapy by reducing NRF2 expression.

13 citations

humanbulk RNA-seq

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BioinformaticsbioRxivPreprintMay 20, 2021

A Facile Immunopeptidomics Workflow for Capturing the HLA-I Ligandome with PEAKS XPro

Kyle S. Hoffman, Baozhen Shan, Jonathan R. Krieger

This paper introduces an immunopeptidomics workflow using PEAKS XPro to identify HLA-I ligands and neoantigens without relying on standard databases, revealing diverse peptides and mutations in colorectal cancer.

2 citations

humanproteomics

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