Koichiro M. Hirosawa

This study uses single-molecule imaging to show that opioid receptors form transient homodimers, with distinct functional effects on signaling and internalization depending on the receptor subtype.

This study identifies the mechanisms by which recipient cells internalize small extracellular vesicles via paracrine adhesion signaling involving galectin-3, LAMP-2C, and Ca2+-dependent pathways.

The paper shows tumor-derived extracellular vesicles bind to laminin via integrins and GM1, inducing cell responses.