Rinshi S. Kasai

A positional and combinatorial regulatory code for alternative splicing

This paper introduces SCALE-CLIP, a method to generate comparable RBP binding maps, and defines a positional and combinatorial regulatory code for alternative splicing.

Single-molecule detection of transient dimerization of opioid receptors 2: Heterodimer blockage reduces morphine tolerance

The paper uses single-molecule imaging to study opioid receptor heterodimerization and shows that blocking MOR-DOR heterodimers reduces morphine tolerance in mice.

Single-molecule detection of transient dimerization of opioid receptors 1: Homodimers' effect on signaling and internalization

This study uses single-molecule imaging to show that opioid receptors form transient homodimers, with distinct functional effects on signaling and internalization depending on the receptor subtype.

The uptake of small extracellular vesicles by recipient cells is facilitated by paracrine adhesion signaling

This study identifies the mechanisms by which recipient cells internalize small extracellular vesicles via paracrine adhesion signaling involving galectin-3, LAMP-2C, and Ca2+-dependent pathways.

Extracellular vesicles adhere to cells primarily by interactions of integrins and GM1 with laminin

The paper shows tumor-derived extracellular vesicles bind to laminin via integrins and GM1, inducing cell responses.