Akihiro Kusumi

Single-molecule detection of transient dimerization of opioid receptors 2: Heterodimer blockage reduces morphine tolerance

The paper uses single-molecule imaging to study opioid receptor heterodimerization and shows that blocking MOR-DOR heterodimers reduces morphine tolerance in mice.

Single-molecule detection of transient dimerization of opioid receptors 1: Homodimers' effect on signaling and internalization

This study uses single-molecule imaging to show that opioid receptors form transient homodimers, with distinct functional effects on signaling and internalization depending on the receptor subtype.

SynGAP forms biocondensates at sub-micromolar concentrations and recruits PSD95 and receptor oligomers, functioning as a key initiator of PSD formation

This study shows SynGAP forms condensates at low concentrations and recruits PSD95 and receptor oligomers, suggesting it initiates PSD formation.

Live cell imaging of single neurotrophin receptor molecules on human neuron in Alzheimer's disease

The paper examines surface dynamics of TrkA and p75NTR receptors in AD neurons and finds altered diffusion rates in AD patients compared to healthy controls.

Single-molecule analysis reveals the rapid effect of estradiol on the surface movement of AMPAR in live neurons

This study uses live-cell single-molecule imaging to show that estradiol rapidly and dose-dependently alters AMPAR surface movement in neurons, with effects varying between somas and neurites.