Single-molecule detection of transient dimerization of opioid receptors 1: Homodimers' effect on signaling and internalization
Peng Zhou, Taka Aki Tsunoyama, Rinshi S. Kasai, Koichiro M. Hirosawa, Ziya Kalay, Amine Aladağ, Takahiro K Fujiwara, Tatsushi Yokoyama, Masayuki Sakamoto, Ryoji Kise, Masataka Yanagawa, Asuka Inoue, Simone Pigolotti A, Akihiro Kusumi
This study uses single-molecule imaging to show that opioid receptors form transient homodimers, with distinct functional effects on signaling and internalization depending on the receptor subtype.
Nature Communications · Nov 7, 2025Peer-reviewedBiophysics