Author

Leo Yamada

National Institutes of HealthORCID 0000-0003-0179-4802Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Curtis C. HarrisiD· 3 shared Izumi HorikawaiD· 3 shared Huaitian LiuiD· 2 shared Natalia von MuhlineniD· 2 shared Drew WeissmaniD· 1 shared Hamideh ParhiziD· 1 shared Jilian R. MelamediD· 1 shared Shinji NakamichiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 31 mutual co-author links

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3 shared papersPhysiology

Curtis C. HarrisORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

PhysiologybioRxivPreprintFeb 7, 2026

Senescence-inhibitory Δ133p53α counteracts accelerated ageing and mortality

Leo Yamada, Huaitian Liu, Natalia von Muhlinen…·Izumi Horikawa

This study shows that Δ133p53α extends lifespan and improves tissue health in a progeria mouse model, suggesting potential therapeutic applications for both progeria and ageing.

DOI 10.64898/2025.12.31.697195

mouseexperimental assay

PhysiologyGeromedicinePeer-reviewedJan 1, 2026

The senescence-inhibitory p53 isoform Δ133p53α represses the proinflammatory chemokine CXCL10 in progeria model mice and naturally aged mice

Leo Yamada, Huaitian Liu, Curtis C. Harris, Izumi Horikawa

This study shows that Δ133p53 reduces CXCL10 levels in progeria and aged mice, linking it to anti-inflammatory effects.

DOI 10.70401/geromedicine.2026.0035

mousebulk RNA-seq

Cancer BiologyCarcinogenesisPeer-reviewedOct 1, 2025

SRSF3 knockdown-induced cellular senescence as a possible therapeutic strategy for non-small cell lung cancer

Shinji Nakamichi, Natalia von Muhlinen, Leo Yamada…·Curtis C. Harris

This study shows that knocking down SRSF3 induces cellular senescence in NSCLC cells, including those without targetable mutations, suggesting a potential new therapeutic strategy.

4 citations

humanbulk RNA-seq