Natalia von Muhlinen

Senescence-inhibitory Δ133p53α counteracts accelerated ageing and mortality

This study shows that Δ133p53α extends lifespan and improves tissue health in a progeria mouse model, suggesting potential therapeutic applications for both progeria and ageing.

SRSF3 knockdown-induced cellular senescence as a possible therapeutic strategy for non-small cell lung cancer

This study shows that knocking down SRSF3 induces cellular senescence in NSCLC cells, including those without targetable mutations, suggesting a potential new therapeutic strategy.

Pharmacologic activation of Δ133p53α reduces cellular senescence in progeria patients-derived cells

This study shows that celastrol and AZD1981 increase Δ133p53 levels and reduce senescence and IL-6 secretion in HGPS-derived fibroblasts, independent of progerin levels.

Microbiome-TP53 Gene Interaction in Human Lung Cancer

This study identifies a microbiome-TP53 interaction in squamous cell lung cancer, showing Acidovorax enrichment in smokers with TP53 mutations.