Hamideh Parhiz

SRSF3 knockdown-induced cellular senescence as a possible therapeutic strategy for non-small cell lung cancer

This study shows that knocking down SRSF3 induces cellular senescence in NSCLC cells, including those without targetable mutations, suggesting a potential new therapeutic strategy.

Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape without Side Effects

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.

In vivo anti-FAP CAR T therapy reduces fibrosis and restores liver homeostasis in metabolic dysfunction-associated steatohepatitis

This study evaluates in vivo anti-FAP CAR T therapy for MASH, showing reduced fibrosis and restored liver homeostasis through HSC depletion and immune modulation.

Unlocking the therapeutic potential of the corneal endothelium: Intravital imaging reveals endogenous regenerative capabilities

This study uses intravital imaging to show corneal endothelial cells can regenerate in mice, and develops a therapeutic approach using modified mRNA to stimulate regeneration in aged mice.