Tao Qi

Closely related type II-C Cas9 orthologs recognize diverse PAMs

The paper identifies type II-C Cas9 orthologs with diverse PAM recognition capabilities, enhancing allele-specific genome editing.

BEdeepon: an in silico tool for prediction of base editor efficiencies and outcomes

BEdeepon predicts base editor efficiencies and outcome sequences using deep learning models trained on high-throughput screening data.

BEdeepoff: an in silico tool for off-target prediction of ABE and CBE base editors

BEdeepoff predicts off-target editing efficiencies for ABE and CBE base editors using deep learning models trained on high-throughput screening data.

Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity

The paper identifies and engineers a compact SlugCas9 variant with broad targeting range, high specificity, and activity for genome editing.