The paper analyzes whole genome sequences of 150,119 UK Biobank individuals, identifying variants and associations with traits, and provides a haplotype reference panel for imputation.

Nature · Jul 20, 2022Peer-reviewedGenetics

Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independent of body mass index

April E. Hartley, Eleanor C. M. Sanderson, Raquel Granell, Lavinia Paternoster, Jie Zheng, George Davey Smith, Lorraine Southam, Konstantinos Hatzikotoulas, Cindy Germaine Boer, Joyce B. J. van Meurs, Eleftheria Zeggini, Lilja Stefánsdóttir, Yanfei Zhang, Rodrigo Coutinho de Almeida, Tian T. Wu, , Jonathan H. Tobias

This study uses multivariable Mendelian randomization to show that higher bone mineral density causally increases osteoarthritis risk independently of body mass index.

International Journal of Epidemiology · Nov 15, 2021Peer-reviewedGenetic & Genomic Medicine

The genetic architecture of osteoarthritis: insights from UK Biobank

Eleni Zengini, Konstantinos Hatzikotoulas, Ioanna Tachmazidou, Julia Steinberg, Fernando Pires Hartwig, Lorraine Southam, Sophie Hackinger, Cindy Germaine Boer, Unnur Styrkársdóttir, Arthur Gilly, Dániel Süveges, Britt Kilian, Þorvaldur Ingvarsson, Helgi Jónsson, George C. Babis, , Eleftheria Zeggini

This study identifies 9 new osteoarthritis loci using UK Biobank data and finds causal effects of higher body mass index on osteoarthritis.

Nature Genetics · Mar 20, 2018Peer-reviewedGenetics