Rodrigo Coutinho de Almeida

ExocubeBio is a miniaturized platform for exposing microbes to space conditions, enabling in-situ measurements and sample return for analysis.

This paper investigates how a COL6A3 mutation affects chondrocyte response to mechanical stress in a human iPSC-derived cartilage organoid model, finding reduced PCM protein binding and impaired stress response.

The paper identifies transcript SNPs with allelic expression imbalance in OA risk loci from articular cartilage and subchondral bone, revealing new potential OA risk genes.

This study uses multivariable Mendelian randomization to show that higher bone mineral density causally increases osteoarthritis risk independently of body mass index.

The paper identifies differentially expressed genes in OA subchondral bone and cartilage using RNA sequencing, highlighting IL11 and CHADL as potential druggable targets.

The paper identifies differentially expressed lncRNAs in OA cartilage and validates their regulatory role on adjacent genes.