Author

Aleksandra Helwak

Wellcome Centre for Cell BiologyORCID 0000-0003-0188-7515Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

David W. TollerveyiD· 4 shared Tomasz W. TurowskiiD· 2 shared A. Arockia Jeyaprakash· 1 shared Alejandro D. IglesiasiD· 1 shared Alyssa L. RippertiD· 1 shared Amy Feldman Lewanda· 1 shared Ana Cazurro‐GutiérreziD· 1 shared Ana Laura Cazurro Gutiérrez· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersMolecular Biology

David W. TollerveyORCID

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4 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMay 21, 2026

Isotope-Free Mapping of protein:RNA Interactions Using fCRAC and trxtools

Nic Robertson, Jan Mikolajczyk, Andrea Cecilia Garcia-Sandoval…·Tomasz W. Turowski

The paper introduces fCRAC, a method for high-resolution mapping of protein:RNA interactions without radioactive labeling, and provides trxtools for analysis, revealing interactions of CYCLON/CCDC86 with rRNA, tRNA, and ncRNAs.

DOI 10.64898/2026.05.19.726220

humanproteomics

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Genetic & Genomic MedicineNature CommunicationsPeer-reviewedFeb 17, 2025

RNA methyltransferase SPOUT1/CENP-32 links mitotic spindle organization with the neurodevelopmental disorder SpADMiSS

Avinash V. Dharmadhikari, Maria Alba Abad, Reza Maroofian…·Universitat Autònoma de Barcelona. Departament de Medicina

The paper identifies SPOUT1/CENP-32 as a causative gene for SpADMiSS, linking its dysfunction to mitotic spindle defects and neurodevelopmental disorders.

DOI 10.1038/s41467-025-56876-w

zebrafishwhole-exome sequencing

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Molecular BiologybioRxivPreprintJan 14, 2022

The RNA-binding landscape of HAX1 protein indicates its involvement in ribosome biogenesis and translation.

Anna Balcerak, Ewelina Macech-Klicka, Maciej Wakuła…·Ewa Anna Grzybowska

The paper identifies HAX1 RNA targets and shows its role in ribosome biogenesis and translation, linking it to disease mechanisms.

DOI 10.1101/2022.01.14.476349

humanbulk RNA-seq

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Molecular BiologyMolecular CellPeer-reviewedJun 24, 2020

Nascent transcript folding plays a major role in determining RNA polymerase elongation rates

Tomasz W. Turowski, Elisabeth Petfalski, Benjamin D. Goddard…·David W. Tollervey

The paper investigates how nascent transcript folding and G+C-content influence RNA polymerase elongation rates in vivo and confirms these effects through in vitro experiments and a mathematical model.

76 citations

yeastChIP-seq

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