David W. Tollervey

The paper examines how RNA-protein interactions change in memory and cytotoxic T cells under low glucose stress, revealing distinct metabolic and functional responses.

The paper introduces fCRAC, a method for high-resolution mapping of protein:RNA interactions without radioactive labeling, and provides trxtools for analysis, revealing interactions of CYCLON/CCDC86 with rRNA, tRNA, and ncRNAs.

This study identifies CYCLON as a nucleolar protein that regulates cancer cell fitness by controlling ribosome biogenesis and nucleolar structure across multiple tumor types.

The paper shows that yeast rapidly adapts to glucose depletion by using metabolic changes to control translation, prioritizing stress-response genes.

The paper identifies SPOUT1/CENP-32 as a causative gene for SpADMiSS, linking its dysfunction to mitotic spindle defects and neurodevelopmental disorders.

This study maps the transcriptional and translational changes in human lung fibroblasts infected with HCoV-OC43, identifying new ORFs and ER stress response activation.

The paper introduces reCRAC, a method for mapping protein-RNA interactions in yeast, improving precision and reducing protein degradation compared to existing techniques.

This study identifies Pin4 as a yeast RNA-binding protein that coordinates post-transcriptional and transcriptional responses to energy depletion by regulating mRNA binding and transcriptional shifts during glucose withdrawal.

This study improves RNA-interactome detection using DIA SILAC over DDA SILAC, achieving higher protein detection and lower variation with single-shot analysis.

The paper investigates transcription termination by RNA polymerase I, showing that 3-end cleavage and backtracking promote termination, with biophysical modeling suggesting ~10% premature termination.

The paper identifies the SPARC complex in Trypanosoma brucei, showing it defines RNAPII promoters and regulates transcription start site positioning and directionality.

The paper identifies EZH2's interaction with MEG3 to regulate integrin signaling and endothelial cell function through epigenetic mechanisms.

The paper identifies HAX1 RNA targets and shows its role in ribosome biogenesis and translation, linking it to disease mechanisms.

The paper investigates how nascent transcript folding and G+C-content influence RNA polymerase elongation rates in vivo and confirms these effects through in vitro experiments and a mathematical model.

The paper identifies three TRAMP complexes in yeast and shows Trf4/Trf5 confer substrate specificity, with TRAMP binding co-enriching functionally related mRNAs.

The paper introduces iRAP, a method to identify RNA-binding sites across the proteome, finding 1331 sites in 324 yeast proteins, many outside known domains.