Simone Mattei

Super-Resolution Processing Enables In Situ Subtomogram Averaging Beyond the Nyquist Limit

This paper demonstrates that super-resolution processing of electron-event representation data can recover biologically meaningful information beyond the physical Nyquist limit in in situ subtomogram averaging.

Dual apical methyltransferases orchestrate motility initiation in apicomplexan parasites

The paper identifies two methyltransferases, PCKMT and AKMT, that regulate motility initiation in apicomplexan parasites through coordinated actin nucleation and force propagation.

LowDoseWizard - rapid and standardised setup of low-dose cryo-TEM imaging in SerialEM

LowDoseWizard streamlines low-dose cryo-TEM setup in SerialEM, reducing setup time and improving reproducibility for high-resolution cryo-EM data collection.

EasyGrid: A versatile platform for automated cryo-EM sample preparation and quality control

EasyGrid automates cryo-EM sample preparation and quality control, improving vitrification for macromolecules and mammalian cells.

PinCorr: A high-pressure freezing carrier with intrinsic landmarks for cryo-correlative light and electron microscopy

PinCorr is a high-pressure freezing carrier with built-in landmarks that enable reliable spatial referencing for cryo-correlative light and electron microscopy.

A Novel Eukaryotic Ribosome Factor Enables Translation Restart Following Cellular Dormancy

The paper identifies SNOR, a ribosome-associated factor in S. pombe, that enables translation restart after cellular dormancy induced by glucose depletion.

The In Situ Structure and Distribution of V-ATPase in C. elegans Apical Membrane Stacks

The paper examines the structure and distribution of V-ATPase in C. elegans apical membrane stacks using cryo-ET, showing they form clusters and acidify the cuticle.

Ice thickness control and measurement in the VitroJet for time-efficient single particle structure determination

The paper develops a method to measure and control ice thickness in the VitroJet for cryo-EM, improving efficiency in single particle structure determination.

Hibernating ribosomes tether to mitochondria as an adaptive response to cellular stress during glucose depletion

This study identifies hibernating ribosomes tethered to mitochondria as an adaptive response to glucose depletion in fission yeast, showing their role in cell survival.

The translating bacterial ribosome at 1.55 A resolution by open access cryo-EM

The paper determines the structure of the translating bacterial ribosome at 1.55 Å resolution using open access cryo-EM, enabling detailed analysis of ribosome polymorphism and drug design.

Mechanism of RNA Polymerase I selection by transcription factor UAF

The paper determines the structure of UAF bound to DNA and TBP to reveal how UAF selects RNA Polymerase I for ribosome biogenesis and mediates specific protein-DNA interactions.