Molecular BiologyCellsPeer-reviewed
Bromodomain protein inhibition protects β-cells from cytokine-induced death and dysfunction via antagonism of NF-κB pathway.
Vinny Negi, Jeongkyung Lee, Varun Mandi…·Vijay K. Yechoor
This study shows that BET inhibitor I-BET protects β-cells from cytokine-induced death and dysfunction by inhibiting NF-κB signaling and preserving key β-cell genes.