Ke Ma

This study identifies the circadian clock's role in coordinating the Notch-to-Wnt signaling switch to enhance regenerative myogenesis in muscle stem cells.

This study shows the circadian clock coordinates Notch and Wnt signaling in muscle stem cells to regulate regeneration, with functional effects in dystrophic muscle and human myoblasts.

This study identifies Quercetin and Fisetin as clock-activating compounds that inhibit adipocyte growth and lipid metabolism via RORα activation.

This paper identifies novel clock activators, chlorhexidine and CM002, that suppress adipocyte development and hypertrophy, leading to anti-obesity effects in mice.

This study shows STX4 is essential for mitochondrial homeostasis in skeletal muscle by regulating mitochondrial biogenesis and mitophagy.

This study shows naringenin modulates the circadian clock via RORα to suppress lipogenesis and promote adipose browning, improving metabolic health.

This study shows that BET inhibitor I-BET protects β-cells from cytokine-induced death and dysfunction by inhibiting NF-κB signaling and preserving key β-cell genes.

This paper identifies chlorhexidine as a circadian clock activator that promotes myogenesis through enhanced CLOCK/Bmal1 transcriptional activity.

This study shows TEAD1 regulates adult β-cell proliferation and function, maintaining glucose homeostasis by balancing quiescence and mature identity in mice and humans.