Author

Wenhui He

Broad InstituteORCID 0009-0006-1165-4351Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Andi PaniD· 1 shared Baodan Hu· 1 shared Charles C. BaileyiD· 1 shared Dongzhi Wu· 1 shared Gogce C. CryneniD· 1 shared Hong ZhengiD· 1 shared Huihui MouiD· 1 shared Jiansong CheniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

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10 top collaborators · 21 mutual co-author links

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1 shared paperBioengineering

Andi PanORCID

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2 papers

Recent·Most cited

BioengineeringNature Biomedical EngineeringPeer-reviewedDec 5, 2024

In vivo affinity maturation of the HIV-1 Env-binding domain of CD4

Andi Pan, Charles C. Bailey, Tianling Ou…·Wenhui He

This study demonstrates that non-antibody protein biologics can undergo affinity maturation in vivo, leading to improved binding affinity and neutralization potency against HIV-1.

15 citations

mouseproteomics

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Evolutionary BiologybioRxivPreprintOct 28, 2024

Cross-Species Analysis Reveals No Universal Programmed Aging Mechanism: Insights from Single-Cell Transcriptomics in Zebrafish, Fruit Fly, and Nematode

Yunhui Niu, Dongzhi Wu, Sen Zhang…·Li Chen

This study uses single-cell transcriptomics across zebrafish, fruit fly, and nematode to show no universal programmed aging mechanism, finding species-specific gene regulatory patterns.

1 citation

zebrafishDrosophila

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