Author

Eileen M. Lynch

Washington University in St. LouisORCID 0000-0003-0214-5046Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pathology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Conrad Chris WeihliD· 2 shared Jil DawiD· 2 shared Sara K. Pittman· 2 shared Alan PestronkiD· 1 shared Chiseko IkenagaiD· 1 shared Cindy V. LyiD· 1 shared Dhruva D. DhavaleiD· 1 shared Meredith E. JackreliD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPathology

Conrad Chris WeihlORCID

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2 papers

Recent·Most cited

PathologybioRxivPreprintSep 21, 2026

VCP is a critical component for TDP-43 disaggregase activity in skeletal muscle

Eileen M. Lynch, Sara K. Pittman, Jil Daw, Conrad Chris Weihl

This study investigates how VCP mutations affect TDP-43 aggregate clearance in skeletal muscle, finding reduced clearance capacity in vitro and in vivo.

DOI 10.64898/2026.09.14.751559

mouseprotein structure

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PathologyScience Translational MedicinePeer-reviewedNov 27, 2024

Seeding competent TDP-43 persists in human patient and mouse muscle

Eileen M. Lynch, Sara K. Pittman, Jil Daw…·Conrad Chris Weihl

This study shows that TDP-43 aggregate seeds persist in both mouse and human skeletal muscle even after the removal of large TDP-43 inclusions.

25 citationstop 3%

humanmouse

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