Cindy V. Ly

Characterizing shared and distinctive molecular phenotypes across motor regions in ALS with and without TDP-43 pathology in a veteran cohort

The paper identifies senescence-associated molecular states in ALS motor neurons, showing regional and pathological differences but shared senescence features across ALS subtypes.

Distribution of big tau isoforms in the human central and peripheral nervous system

The paper characterizes big tau isoforms in human nervous system tissues and CSF, finding they are enriched in the peripheral nervous system and largely unaffected by neurodegenerative disease.

miR-146a is a Pleiotropic Regulator of Motor Neuron Degeneration

The paper shows miR-146a regulates multiple aspects of motor neuron degeneration in ALS, with genetic deletion extending survival and causing age-related paralysis and inflammation.

Network Analysis of the Cerebrospinal Fluid Proteome Reveals Shared and Unique Differences Between Sporadic and Familial Forms of Amyotrophic Lateral Sclerosis

The paper identifies proteomic differences in cerebrospinal fluid between sporadic and familial ALS subtypes using network analysis and validates biomarkers across neurodegenerative diseases.

Seeding competent TDP-43 persists in human patient and mouse muscle

This study shows that TDP-43 aggregate seeds persist in both mouse and human skeletal muscle even after the removal of large TDP-43 inclusions.