Expression of Fibroblast Growth Factor Receptor 3 (FGFR3) in the Human Peripheral Nervous System: Implications for the Putative Pathogenic Role of FGFR3 Autoantibodies in Neuropathy
Alexander G. Chamessian, Diana Tavares‐Ferreira, Maria Payne, Raghav Govindarajan, Alan Pestronk, Zach Bertels, Allie J. Widman, Richard A. Slivicki, John Smith Del Rosario, Jiwon Yi, Bryan A. Copits, David M. Ornitz, Theodore John Price, Robert W. Gereau
The paper investigates FGFR3 expression in human peripheral nervous system tissues and finds no detectable mRNA or protein expression in nerve or dorsal root ganglia, suggesting FGFR3 autoantibodies may not directly cause neuropathy.
bioRxiv · Mar 3, 2025 · PreprintNeuroscience