Judi O’Shaughnessy

Amygdala TDP-43 pathology is associated with behavioural dysfunction and ferritin accumulation in amyotrophic lateral sclerosis.

The paper shows that amygdala TDP-43 pathology correlates with behavioural dysfunction and ferritin accumulation in sporadic ALS.

Single-molecule validation and optimized protocols for the use of secondary nanobodies in multiplexed immunoassays

This study validates secondary nanobodies for multiplexed immunoassays and provides optimized protocols for their use.

GLP-1 receptor agonism ameliorates Parkinsons disease through modulation of neuronal insulin signalling and glial suppression

This study shows GLP-1R agonism improves Parkinson's disease by restoring neuronal insulin signaling and reducing glial inflammation, with clinical benefits in patients with higher baseline MAPK expression.

RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS

This study uses an RNA aptamer to detect TDP-43 aggregation and shows that nuclear TDP-43 pathology and STMN-2 cryptic splicing occur before clinical symptoms in ALS.

Two-color coincidence single-molecule pull-down for the specific detection of disease-associated protein aggregates

This paper introduces a method to specifically detect disease-associated protein aggregates using two-color coincidence single-molecule pull-down, demonstrating its effectiveness with alpha-synuclein in human biofluids.

Distinct neuroinflammatory signatures exist across genetic and sporadic ALS cohorts

The paper identifies two distinct neuroinflammatory signatures in ALS cohorts using gene expression analysis and validates their association with clinical metrics.

Random forest modelling of neuropathological features identifies microglial activation as an accurate pathological classifier of C9orf72-related amyotrophic lateral sclerosis

The paper uses random forest modelling to identify microglial activation as a key classifier for C9orf72-related ALS and shows spatial FUS staining changes predict disease status.

pTDP-43 aggregates accumulate in the gut and other non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis

The paper identifies pTDP-43 aggregates in non-CNS tissues of ALS patients prior to symptom onset, suggesting systemic pathology beyond the central nervous system.