BiochemistryChemical SciencePeer-reviewed
Targeting the selectivity filter to drastically alter the activity and substrate spectrum of a promiscuous metal transporter
Yuhan Jiang, Michael Nikolovski, Tianqi Wang…·Jian Ping Hu
This study modifies key residues in ZIP8 to alter its metal transport activity and substrate spectrum, identifying variants with enhanced activity and expanded substrate preferences.
3 citations