Timothy A. Fenton

This study characterizes the biophysical and neurophysiological effects of the SCN8A p.(Gly1625Arg) mutation, showing a complex mix of gain-and loss-of-function properties leading to reduced neuronal firing.

This paper investigates functional impairments in Syngap1 mutant mice, identifying translational biomarkers in both in vitro and in vivo neurophysiological data.

This study uses automated gait analysis in an Angelman Syndrome mouse model to identify quantitative motor impairments, showing their translational relevance for therapeutic development.

This study shows that deleting a non-canonical regulatory region of Scn1a in mice leads to reduced Scn1a expression and epileptic symptoms.