A. Ayanna Wade

Persistent cortical excitatory neuron dysregulation in adult Chd8 haploinsufficient mice.

This study identifies persistent excitatory neuron dysfunction in Chd8 haploinsufficient mice through single nucleus transcriptomics and behavioral analysis.

Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice

This study shows that deleting a non-canonical regulatory region of Scn1a in mice leads to reduced Scn1a expression and epileptic symptoms.

Neuroanatomy and Behaviour in Mice with a Haploinsufficiency of AT-Rich Interactive Domain 1B (ARID1B) Throughout Development

This study investigates the effects of Arid1b haploinsufficiency in mice, revealing sex-dependent neuroanatomical and behavioral phenotypes associated with neurodevelopmental disorders.

Novel CHD8 genomic targets identified in fetal mouse brain by in vivo Targeted DamID

This study identifies novel CHD8 genomic targets in fetal mouse brain using in vivo Targeted DamID, revealing binding sites related to neurodevelopment and autism-relevant biology.

CHD8 Regulates Cellular Homeostasis and Neuronal Function Genes Across Multiple Models of CHD8 Haploinsufficiency

This study identifies CHD8 as a critical regulator of gene expression by analyzing transcriptomic and epigenomic data from multiple CHD8 knockdown and knockout models, revealing high-affinity interactions with genes involved in cellular homeostasis and neuronal function.