Alex S. Nord

This study examines the effects of Chd8 haploinsufficiency on cerebellar development and function in mice, revealing cell-type-specific transcriptomic and physiological changes.

The paper develops murine and zebrafish Wac deletion models to study DeSanto-Shinawi Syndrome, finding craniofacial, behavioral, and neurodevelopmental phenotypes similar to the human condition.

The paper develops membrane-targeted TurboID variants for in vivo proteomics in neuronal circuits, identifying subcellular proteins and their changes during acute drug exposure.

The paper presents a model of dynamic spatial and temporal patterning in the embryonic basal ganglia, showing how progenitor movement and transcriptional changes lead to diverse neuronal subtypes.

The paper identifies CHD8 interactions in mouse brain, revealing a role in chromatin-associated RNA processing and highlighting dosage sensitivity in neurodevelopmental disorders.

This study identifies persistent excitatory neuron dysfunction in Chd8 haploinsufficient mice through single nucleus transcriptomics and behavioral analysis.

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

The paper identifies combinatorial TF-cRE interactions in mouse basal ganglia development, revealing modules that drive GABAergic neurogenesis and suppress other fates.

This study links neurotransmitter pathway polygenic risk to specific symptom profiles in psychosis, identifying associations between glutamate and dopamine pathways with cognitive control and global functioning.

This paper investigates functional impairments in Syngap1 mutant mice, identifying translational biomarkers in both in vitro and in vivo neurophysiological data.

The paper identifies shared regulatory targets of autism-associated transcriptional regulators in brain-expressed genes and shows their functional convergence in neurodevelopmental outcomes.

The paper identifies a transcription factor network and enhancers involved in cortical regional patterning using mouse embryonic data.

The paper shows POGZ promotes chromatin accessibility and expression of synaptic genes in mouse and human brains, and its reduction disrupts cortical function through interactions with ADNP.

This study examines transcriptional changes in rat hippocampus after traumatic brain injury, identifying time-dependent gene expression patterns and epigenetic modifications.

The paper identifies and validates enhancers active in early postnatal mouse brain using a modified MPRA approach and rAAV delivery.

This study shows that deleting a non-canonical regulatory region of Scn1a in mice leads to reduced Scn1a expression and epileptic symptoms.

This study investigates the effects of Arid1b haploinsufficiency in mice, revealing sex-dependent neuroanatomical and behavioral phenotypes associated with neurodevelopmental disorders.

This study identifies novel CHD8 genomic targets in fetal mouse brain using in vivo Targeted DamID, revealing binding sites related to neurodevelopment and autism-relevant biology.

The paper investigates whether increased cortical volume in Chd8 mutant mice is due to increased neuron number or soma size, finding no increase in neuron number but increased volume.

The paper uses scRNA-seq and enhancer-based labeling to map neuronal lineages in embryonic mouse basal ganglia and identifies novel lineage specification paths.

This study identifies transcriptomic and neuroanatomical changes in mouse embryos exposed to maternal immune activation, revealing altered neurodevelopmental timing and cortical development.

The paper identifies regulatory elements and transcription factors involved in GABAergic and cholinergic neuron fate maturation during MGE development.

This study identifies CHD8 as a critical regulator of gene expression by analyzing transcriptomic and epigenomic data from multiple CHD8 knockdown and knockout models, revealing high-affinity interactions with genes involved in cellular homeostasis and neuronal function.