Author

Tiia S. Freeman

Fred Hutch Cancer CenterORCID 0000-0003-0275-9005Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:gene regulatory network inference· 1 Assay:multiome· 1

Frequent Co-Authors

Eva M. AllemaniD· 2 shared Harmit Singh MalikiD· 2 shared Michael EmermaniD· 2 shared Tamanash BhattacharyaiD· 2 shared Alexander C. NoyolaiD· 1 shared Fang WangiD· 1 shared Kevin M. MylesiD· 1 shared Lyuba ChechikiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

Eva M. AllemanORCID

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2 papers

Recent·Most cited

MicrobiologyScience AdvancesPeer-reviewedJun 17, 2026

A conserved in-frame stop codon acts as a multipotent defense mechanism in alphaviruses

Tamanash Bhattacharya, Tiia S. Freeman, Eva M. Alleman…·Harmit Singh Malik

This study shows that an in-frame stop codon in alphaviruses helps evade innate immune defenses in both mosquito and vertebrate hosts.

3 citationstop 1%

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MicrobiologyScience AdvancesPeer-reviewedApr 18, 2025

A conserved opal termination codon optimizes a temperature-dependent tradeoff between protein production and processing in alphaviruses

Tamanash Bhattacharya, Eva M. Alleman, Tiia S. Freeman…·Harmit Singh Malik

This study shows that the opal stop codon in alphaviruses optimizes protein production and processing at 37°C by balancing polymerase levels and RNA replication transitions.

10 citations

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