Author

Eva M. Alleman

Fred Hutch Cancer CenterORCID 0009-0005-6765-9939Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1 Assay:multiome· 1

Frequent Co-Authors

Harmit Singh MalikiD· 2 shared Michael EmermaniD· 2 shared Tamanash BhattacharyaiD· 2 shared Tiia S. FreemaniD· 2 shared Alexander C. NoyolaiD· 1 shared Arvind Rasi SubramaniamiD· 1 shared Christopher P. LapointeiD· 1 shared Fang WangiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersMicrobiology

Harmit Singh MalikORCID

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3 papers

Recent·Most cited

MicrobiologyScience AdvancesPeer-reviewedJun 17, 2026

A conserved in-frame stop codon acts as a multipotent defense mechanism in alphaviruses

Tamanash Bhattacharya, Tiia S. Freeman, Eva M. Alleman…·Harmit Singh Malik

This study shows that an in-frame stop codon in alphaviruses helps evade innate immune defenses in both mosquito and vertebrate hosts.

3 citationstop 1%

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BiophysicsbioRxivPreprintMar 27, 2026

A codon-sensitive conformational switch gates commitment to translation start sites

Sydney F. McGuire, Matthew C. Chan, Tung Ching Chan…·Christopher P. Lapointe

The paper identifies a conformational switch in eIF5 that regulates translation initiation at AUG and non-AUG codons by stabilizing or destabilizing the initiation complex.

DOI 10.64898/2026.03.24.713952

humanprotein structure

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MicrobiologyScience AdvancesPeer-reviewedApr 18, 2025

A conserved opal termination codon optimizes a temperature-dependent tradeoff between protein production and processing in alphaviruses

Tamanash Bhattacharya, Eva M. Alleman, Tiia S. Freeman…·Harmit Singh Malik

This study shows that the opal stop codon in alphaviruses optimizes protein production and processing at 37°C by balancing polymerase levels and RNA replication transitions.

10 citations

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