Author

Tamanash Bhattacharya

Fred Hutch Cancer CenterORCID 0000-0002-8129-7568Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

Harmit Singh MalikiD· 3 shared Eva M. AllemaniD· 2 shared Michael EmermaniD· 2 shared Tiia S. FreemaniD· 2 shared Adam T. FishburniD· 1 shared Alexander C. NoyolaiD· 1 shared Amelia R. I. LindseyiD· 1 shared Avery E. RobertsoniD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersMicrobiology

Harmit Singh MalikORCID

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Author profile →

4 papers

Recent·Most cited

A conserved in-frame stop codon acts as a multipotent defense mechanism in alphaviruses

Tamanash Bhattacharya, Tiia S. Freeman, Eva M. Alleman, Fang Wang, Lyuba Chechik, Michael Emerman, Kevin M. Myles, Harmit Singh Malik

This study shows that an in-frame stop codon in alphaviruses helps evade innate immune defenses in both mosquito and vertebrate hosts.

Science Advances · Jun 17, 2026Peer-reviewedMicrobiology

Yellow Fever Virus Interactomes Reveal Common and Divergent Strategies of Replication and Evolution for Mosquito-borne Flaviviruses

Matthew W. Kenaston, Liubov Cherkashchenko, Chase L. S. Skawinski, Adam T. Fishburn, Vardhan Peddamallu, Cole J. Florio, Avery E. Robertson, Tamanash Bhattacharya, Janet M. Young, Harmit Singh Malik, Priya S. Shah

The paper maps YFV interactomes in human and mosquito cells, identifies RBBP6 as a restriction factor, and reveals divergent host interaction strategies among flaviviruses.

bioRxiv · Jun 14, 2025 · PreprintSystems Biology

A conserved opal termination codon optimizes a temperature-dependent tradeoff between protein production and processing in alphaviruses

Tamanash Bhattacharya, Eva M. Alleman, Tiia S. Freeman, Alexander C. Noyola, Michael Emerman, Harmit Singh Malik

This study shows that the opal stop codon in alphaviruses optimizes protein production and processing at 37°C by balancing polymerase levels and RNA replication transitions.

Science Advances · Apr 18, 2025Peer-reviewedMicrobiology

Common Analysis of Direct RNA SequencinG CUrrently Leads to Misidentification of 5-Methylcytosine Modifications at GCU Motifs

Kaylee J. Watson, Robin E. Bromley, Benjamin C. Sparklin, Mark T. Gasser, Tamanash Bhattacharya, Jarrett F. Lebov, Tyonna S. Tyson, Laura E. Teigen, Karen T. Graf, Michelle L. Michalski, Vincent M. Bruno, Amelia R. I. Lindsey, Richard W. Hardy, Irene L. G. Newton, Julie C. Dunning Hotopp

The paper identifies a false positive in m5C detection by Tombo in GCU motifs across diverse RNA samples, suggesting published findings should be re-evaluated.

bioRxiv · May 3, 2023 · PreprintGenomics