Kevin M. Myles

A conserved in-frame stop codon acts as a multipotent defense mechanism in alphaviruses

This study shows that an in-frame stop codon in alphaviruses helps evade innate immune defenses in both mosquito and vertebrate hosts.

Exploiting attP landing sites and gypsy retrovirus insulators to identify and study viral suppressors of RNA silencing

This study evaluates how genomic insertion sites affect VSR activity in Drosophila using a transgenic reporter system and shows that gypsy retrovirus insulators can standardize silencing across loci.

Enhancing Tissue-Specific Antiviral Immunity to Disrupt Arbovirus Transmission by Mosquitoes

This study identifies tissue-specific antiviral mechanisms in mosquitoes, showing that enhancing Dicer2 in salivary glands reduces arbovirus transmission.

Repeat mediated excision of gene drive elements for restoring wild-type populations

This paper demonstrates a gene drive mitigation strategy using Repeat Mediated Excision of a Drive Element (ReMEDE) to replace drive alleles with wild-type alleles in Drosophila melanogaster.

Exposure to cooler temperatures during pupal development increases Aedes aegypti vector competence and the R0 for Zika virus

This study shows that cooler temperatures during the pupal stage of Aedes aegypti increase vector competence for Zika virus and raise its R0.