Constance Lamy

This paper develops a single-nucleus multimodal framework to analyze transcriptional and histone modification landscapes in ovarian cancer, revealing epigenomic priming of chemoresistant states and its impact on treatment outcomes.

This study shows that AGuIX nanoparticles and their combination with ionizing radiation induce proinflammatory reprogramming of tumor-associated macrophages via AMPK-dependent mitochondrial fragmentation.