Evolutionary BiologybioRxivPreprint
Population bottlenecks shape laboratory evolution of piperacillin-tazobactam resistance in Klebsiella grimontii and reveal a shared within-patient evolutionary trajectory
Ellie Allman, Aakash Khanijau, Rachel J. McGalliard…·Adam Paul Roberts
This study compares laboratory evolution of piperacillin-tazobactam resistance in Klebsiella grimontii with within-patient resistance evolution, showing that small population bottlenecks reproduce key resistance mechanisms observed in clinical isolates.
DOI 10.64898/2026.06.15.732307