Population bottlenecks shape laboratory evolution of piperacillin-tazobactam resistance in Klebsiella grimontii and reveal a shared within-patient evolutionary trajectory
Ellie Allman, Aakash Khanijau, Rachel J. McGalliard, Richard N. Goodman, Christopher Parry, Enitan D. Carrol, Nicholas Feasey, Fabrice E. Graf, Adam Paul Roberts
This study compares laboratory evolution of piperacillin-tazobactam resistance in Klebsiella grimontii with within-patient resistance evolution, showing that small population bottlenecks reproduce key resistance mechanisms observed in clinical isolates.
bioRxiv · Jun 16, 2026 · PreprintEvolutionary Biology