ImmunologybioRxivPreprint
Clonal autoantibodies identify microbial antigen as trigger of autoreactive B cells in systemic sclerosis
Sam Neppelenbroek, Sophie I E Liem, Theo van Laar…·Hans Ulrich Scherer
The paper identifies microbial antigen, specifically fungal topoisomerase 1, as a trigger for autoreactive B cells in systemic sclerosis by showing cross-reactivity between human and microbial TOP1.
DOI 10.64898/2026.03.17.712484