Author

Sam Neppelenbroek

Leiden University Medical CenterORCID 0000-0002-9582-2837Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

Corrie M. WorteliD· 2 shared Cynthia M. FehresiD· 2 shared E. W. Nivine LevarhtiD· 2 shared Hans Ulrich SchereriD· 2 shared René E.M. ToesiD· 2 shared Albert J. R. HeckiD· 1 shared Bart EvertsiD· 1 shared Danique M.H. van RijswijckiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

Corrie M. WortelORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Enhanced recognition of topoisomerase 1 upon DNA binding by a subset of anti-topoisomerase 1 autoantibodies in systemic sclerosis

Sam Neppelenbroek, Corrie M. Wortel, Danique M.H. van Rijswijck, Marjolein J.A.L. Wetzels, Robbert Q. Kim, Nikki M. Loof, Martina Erbì, E. W. Nivine Levarht, Bart Everts, Albert J. R. Heck, de Vries-Bouwstra Jk, Cynthia M. Fehres, René E.M. Toes, Hans Ulrich Scherer

This study shows that some anti-topoisomerase 1 autoantibodies (ATAs) in systemic sclerosis (SSc) bind more strongly to TOP1-DNA cleavage complexes, correlating with disease severity and immune activation.

Annals of the Rheumatic Diseases · Apr 12, 2026Peer-reviewedImmunology

Clonal autoantibodies identify microbial antigen as trigger of autoreactive B cells in systemic sclerosis

Sam Neppelenbroek, Sophie I E Liem, Theo van Laar, Eva M. Hoekstra, Corrie M. Wortel, E. W. Nivine Levarht, Cynthia M. Fehres, Nynke H. Dekker, JK de Vries-Bouwstra, René E.M. Toes, Hans Ulrich Scherer

The paper identifies microbial antigen, specifically fungal topoisomerase 1, as a trigger for autoreactive B cells in systemic sclerosis by showing cross-reactivity between human and microbial TOP1.

bioRxiv · Mar 19, 2026 · PreprintImmunology