Author

Mohanraj Gopalswamy

Heinrich Heine University Düsseldorf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Holger GohlkeiD· 3 shared Alexandra Großdorf· 1 shared Anfei HuangiD· 1 shared Aparna Vaidya· 1 shared Christian GorzelannyiD· 1 shared David BickeliD· 1 shared Doreen Manuela FlossiD· 1 shared Jia‐Wey Tu· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiophysics

Holger GohlkeORCID

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3 papers

Recent·Most cited

Dual Carbohydrate Recognition by the Chitinase-like Protein CHI3L1 Through Distinct Glycosaminoglycan and Chitin-Binding Interfaces

Önder Kurç, Nick Rähse, Mohanraj Gopalswamy, Alexandra Großdorf, Christian Gorzelanny, Jonathan Cramer, Holger Gohlke

This study identifies two distinct carbohydrate-binding sites on CHI3L1, showing that chitin oligosaccharides and glycosaminoglycans bind to separate sites with different affinities and regulatory effects.

bioRxiv · Sep 21, 2026 · PreprintBiophysics

The mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin B

Xiaoli Yang, Pablo Cea‐Medina, Mohanraj Gopalswamy, Aparna Vaidya, Sonja Schavier, Shixin Oltzen, Sofie Moßner, Anfei Huang, Jing Qi, Johanna Maria Hölken, Nicole Elisabeth Teusch, Doreen Manuela Floss, Markus Uhrberg, Holger Gohlke, Stefanie Scheu

This study identifies Beauvericin as an uncompetitive inhibitor of Cathepsin B through NMR, enzyme kinetics, and molecular docking analyses in dendritic cells.

Protein Science · May 24, 2025Peer-reviewedBiochemistry

Identification of non-charged 7.44 analogs interacting with the NHR2 domain of RUNX1-ETO and exhibiting an improved, selective antiproliferative effect in RUNX-ETO positive cells

Mohanraj Gopalswamy, David Bickel, Niklas Dienstbier, Jia‐Wey Tu, Melina Vogt, Stephan Schott‐Verdugo, Sanil Bhatia, Manuel Etzkorn, Holger Gohlke

The paper identifies non-charged analogs of the inhibitor 7.44 that show improved antiproliferative effects against RUNX1-ETO positive cells.

Scientific Reports · May 21, 2025Peer-reviewedPharmacology & Toxicology