Kevin M. Goff

This study shows that impaired spike generation and synaptic transmission in parvalbumin interneurons contribute to Dravet syndrome severity and chronic pathology in an experimental model.

This study identifies circuit dysfunction in the hippocampus of a Dravet syndrome mouse model and shows that restoring parvalbumin interneuron function can rescue circuit impairments.

The paper investigates the role of CAST/ELKS in presynaptic development, finding reduced surface area and increased active zone size but no impairment in synaptic transmission.