Karthik Bharadwaj Tallapaka

This study benchmarks nanopore-based DNA methylation detection tools across bacterial, plant, and mammalian datasets, finding older models best for CpG methylation and newer tools better for non-CG methylation.

This study presents whole-genome and transcriptome analyses of breast tumors from India, identifying novel mutations, copy number alterations, and subtypes with clinical implications.

The paper presents a comprehensive genomic atlas of Indian populations, identifying novel variants and highlighting genetic diversity and pharmacogenomic implications.

The paper identifies a perinatal lethal disorder caused by biallelic loss-of-function variants in SERPINA11, showing its role in extracellular matrix remodelling during embryonic development.

The paper develops improved models for detecting 6mA using Nanopore sequencing, achieving higher accuracy than existing methods.

This study identifies transcriptional changes in SARS-CoV-2 infected patients, showing upregulation of innate immunity and downregulation of sensory and neuro-related genes, linked to clinical symptoms.

The paper analyzes SARS-CoV-2 genomes from India, identifying a distinct phylogenetic cluster (Clade I/A3i) that accounts for 41% of Indian isolates and 3.5% globally.

The paper develops an inexpensive RT-nPCR assay for SARS-CoV-2 that matches RT-qPCR performance and highlights low detection efficiency in real-world RT-qPCR testing.

This paper simplifies and improves SARS-CoV-2 detection by removing the RNA isolation step in RT-PCR, making it faster, cheaper, and more efficient without sacrificing accuracy.