Rakesh K. Mishra

The paper investigates the functional roles of ultraconserved non-coding regions near the Hoxd complex in zebrafish by using CRISPR-Cas9 to delete different regions and assess their impact on development and viability.

GenTIGS is a database that compiles information on rare genetic disorders, including genes, variants, symptoms, and prevalence data, with a focus on India.

This study shows that Drosophila melanogaster can pass on increased survivability from parasitic stress exposure through transgenerational epigenetic inheritance.

This study examines how heat stress affects the sperm proteome across generations in Drosophila melanogaster and suggests chromatin-based mechanisms for transmitting heat stress memory.

The paper shows DNMT3L interacts with Piwi and alters piRNA profiles across generations in Drosophila, suggesting a role in epigenetic inheritance.

The paper examines the evolutionary dynamics of triplet nucleotide repeats in vertebrates, highlighting their expansion in primates and association with neurological diseases.

The paper uses CRISPR/Cas9 and FLP-FRT to engineer the cis-regulatory landscape of the Drosophila BX-C to study collinearity and CRM organization.

The paper investigates the role of Satb2 in regulating zygotic genome activation and developmental transitions during vertebrate embryogenesis, showing distinct maternal and zygotic functions.

DiviSSR uses a mathematical property of 2-bit DNA representations to quickly and accurately identify tandem repeats in genomic data.

The paper identifies boundary elements and a Polycomb Response Element that maintain the autonomous regulatory domain of the eyeless gene in Drosophila.

This study identifies transcriptional changes in SARS-CoV-2 infected patients, showing upregulation of innate immunity and downregulation of sensory and neuro-related genes, linked to clinical symptoms.

This study identifies 362 conserved nuclear matrix proteins in Drosophila species, finding 132 originated from prokaryotes and 68 are conserved across all eukaryotes.

The paper investigates how pericentromeric genome organization and chromatin factors regulate heterochromatic gene expression in Drosophila melanogaster using 5C-seq and RNAi experiments.

The paper analyzes SARS-CoV-2 genomes from India, identifying a distinct phylogenetic cluster (Clade I/A3i) that accounts for 41% of Indian isolates and 3.5% globally.

This paper identifies DCP2 as a tumor suppressor in Drosophila melanogaster through a forward genetic screen and validates its role in tumor biology.

The paper develops an inexpensive RT-nPCR assay for SARS-CoV-2 that matches RT-qPCR performance and highlights low detection efficiency in real-world RT-qPCR testing.

This paper presents a high-quality draft genome of Leptopilina boulardi, revealing its epigenetic features and developmental gene conservation, which supports further research on host-parasitoid interactions.

This study identifies the protein-protein interactome of vertebrate GAF/ThPOK, revealing its roles in gene regulation and DNA repair, and suggests its potential as a biomarker for melanoma.

This paper simplifies and improves SARS-CoV-2 detection by removing the RNA isolation step in RT-PCR, making it faster, cheaper, and more efficient without sacrificing accuracy.

This paper shows dIno80 interacts with PREs in Drosophila and can rescue pho mutant lethality, suggesting it functions in cellular memory through non-canonical complexes.

The paper identifies a novel tumour suppressor allele of DCP2 in Drosophila melanogaster and demonstrates its role in tumor suppression through genetic analysis.

This study identifies Choline Transporter (ChT) enrichment in Drosophila mushroom body β core neurons and shows its non-canonical role in regulating pupal eclosion and neuromuscular junction integrity.

The paper analyzes the epigenomic and genomic features of heterochromatic genes in Drosophila melanogaster across developmental stages using modENCODE data, identifying distinct histone modification patterns and regulatory elements.

This study identifies and analyzes microsatellites across 719 eukaryotes, revealing evolutionary trends and species-specific patterns that reflect biological complexity.

C-State is a web app that enables interactive visualization and comparative analysis of epigenetic patterns across multiple genes and cell types.