Rashna Bhandari

This study shows that IP6K1 supports polyphosphate synthesis in mast cell granules by maintaining granule acidification via V-ATPase activity.

This paper shows that 5-InsP7, synthesized by IP6K1, disrupts RAD51 binding to BRCA2-CTD, promoting DNA repair by dislodging RAD51 from DNA damage sites.

This study identifies IP6K1 as a regulator of secretory granule biogenesis in gastric chief cells, impacting protein digestion through its interaction with SDC4.

The paper introduces FRAPPe, a FRET-based biosensor for detecting inorganic polyphosphates, which can quantify polyP levels and is useful for high-throughput screens.

This study identifies IP6K1 as a regulator of mitochondrial polyP synthesis and function, showing its role in energy homeostasis through 5-InsP7 production and a catalytic-independent mechanism.

The paper shows that IP6K1 interacts with proteins that undergo pyrophosphorylation and with CK2, enabling coordinated pre-phosphorylation and pyrophosphorylation of target serine residues.

The paper identifies a perinatal lethal disorder caused by biallelic loss-of-function variants in SERPINA11, showing its role in extracellular matrix remodelling during embryonic development.

This study shows that acetylation of catalytic lysine in CDK1 regulates Cyclin-B binding, with SIRT1 and P300 opposing this modification, and that acetylation mimics in yeast block cell cycle progression.