Author

Leonardo da Silva Augusto

University of Nebraska Medical CenterORCID 0000-0003-0430-8216Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Vern B. CarruthersiD· 2 shared Alfredo J. GuerraiD· 1 shared Benedikt M. MarkusiD· 1 shared Einar B. Olafsson· 1 shared Einar Birnir OlafssoniD· 1 shared Feng‐Rong WangiD· 1 shared Hargobinder KauriD· 1 shared Jonathan Z. SextoniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

Vern B. CarruthersORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJul 23, 2026

Toxoplasma GRA8 engages the host ESCRT accessory protein ALG-2 and is necessary for parasite metabolic integrity

Hargobinder Kaur, Rebekah B. Guevara, Yolanda Rivera-Cuevas…·Vern B. Carruthers

This paper identifies TgGRA8 as a Toxoplasma protein that recruits ALG-2 to the parasitophorous vacuole, essential for parasite metabolism and ESCRT hijacking.

DOI 10.64898/2026.07.20.739547

metabolomicsexperimental assay

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MicrobiologymSpherePeer-reviewedApr 4, 2025

Metabolic Adaptability and Nutrient Scavenging in Toxoplasma gondii: Insights from Ingestion Pathway-Deficient Mutants

Patrick A. Rimple, Einar Birnir Olafsson, Benedikt M. Markus…·Vern B. Carruthers

This study investigates the role of the ingestion pathway in Toxoplasma gondii nutrient acquisition by analyzing mutants lacking key pathway components, revealing reliance on biosynthetic pathways and highlighting the pathway's role in nutrient scarcity.

12 citationstop 1%

humanbulk RNA-seq

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