Author

Alfredo J. Guerra

University of MichiganORCID 0000-0001-8764-8413Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:metabolomics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Aline Sardinha-SilvaiD· 1 shared Beth Gregg· 1 shared Bethany B. MooreiD· 1 shared Björn F.C. KafsackiD· 1 shared Einar B. Olafsson· 1 shared Hargobinder KauriD· 1 shared Jonathan Z. SextoniD· 1 shared Joshua MayoraliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMicrobiology

Aline Sardinha-SilvaORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJul 23, 2026

Toxoplasma GRA8 engages the host ESCRT accessory protein ALG-2 and is necessary for parasite metabolic integrity

Hargobinder Kaur, Rebekah B. Guevara, Yolanda Rivera-Cuevas…·Vern B. Carruthers

This paper identifies TgGRA8 as a Toxoplasma protein that recruits ALG-2 to the parasitophorous vacuole, essential for parasite metabolism and ESCRT hijacking.

DOI 10.64898/2026.07.20.739547

metabolomicsexperimental assay

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MicrobiologybioRxivPreprintMar 17, 2025

Toxoplasma induced cytokine release syndrome is critically dependent on the expression of pore-forming Perforin-Like Protein-1

Beth Gregg, Alfredo J. Guerra, Stephen Raverty…·Michael E. Grigg

This study shows that Toxoplasma gondii's PLP1 protein drives cytokine release syndrome by inducing dysregulated immune responses, leading to lethal inflammation during acute infection.

2 citations

mouseproteomics

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