Noa Beatriz Martin-Cofreces

This study identifies how a single mutation in the Omicron variant of SARS-CoV-2's ORF3a protein alters its host-cell remodelling effects, shifting from lipid accumulation to preserving Golgi structure.

The paper shows that in-gel protein digestion with acidic methanol selectively methylates glutamic acid residues, not other methylable residues like aspartic acid.

ReCom improves peptide identification by using a semi-supervised approach with a reference database, increasing performance by 68% over Comet-PTM.