Mingxia Gu

This study generates human lymphatic organoids from pluripotent stem cells using two mesodermal routes, showing they form functional vascular networks and support immune interactions.

This paper develops a human myelin microphysiological system to test treatment responses in multiple sclerosis patients, showing differential demyelination and immune responses between patient groups.

This paper introduces Brainobot, a biohybrid robotic system using brain organoid reservoir computing to enable real-world decision-making tasks like object grasping and laser chasing with high efficiency and low energy consumption.

This study quantifies information-processing-like properties of human cortical organoids using a functional phenotyping framework, linking network function to disease-related mutations and pharmacological perturbations.

The paper uses vessel organoids to study how different FOXF1 variants affect mesoderm and capillary development in humans, showing variant-specific disruptions and potential therapeutic rescue.

This paper describes a method to generate valvular interstitial cells from human pluripotent stem cells, showing high transcriptional similarity to primary fetal VICs and recapitulating disease features in an in vitro model.

The paper identifies an NTRK2 isoform switch in BPD lungs that impairs endothelial regeneration and shows that restoring full-length NTRK2 mRNA can reverse alveolar damage.

This paper introduces VID scaffolds to enhance diffusion in neural organoids, improving their function and drug response compared to conventional organoids.

This study uses human brain organoid microphysiological systems to show that AD patient monocytes cause increased inflammation and reduced Aβ clearance in organoids compared to controls.

This study creates a gene regulation map of the human fetal heart to interpret genetic variants associated with congenital heart disease and cardiac traits, identifying valvular interstitial cells as key regulators.

The paper identifies a novel APOE+ elastin-producing valve interstitial cell subtype and reveals the APOE-NOTCH signaling axis regulates elastogenesis during human cardiac valve remodeling.

This study develops a human pluripotent stem cell-derived organoid system to investigate vascular, mesenchymal, and epithelial co-development in lung and intestinal organoids, revealing organ-specific endothelial and mesenchymal features.

This study uses single-cell chromatin accessibility analysis to identify developmental trajectories and non-coding mutations associated with congenital heart disease.

This study identifies KMT2D-NOTCH signaling defects in HLHS coronary artery endothelial cells, showing impaired differentiation and proliferation due to suppressed NOTCH target genes.

This study shows that blocking inflammation in preterm primates prevents lung injury, preserving alveolar structure and function similar to chronic lung disease in newborns.

This study uses single-cell RNA sequencing to identify endocardial defects in hypoplastic left heart syndrome, linking them to abnormal valve and septum development.