Hugues Abriel

This study shows that the inhibitor PBA binds to TRPM4 in different locations at 8°C and 37°C, revealing temperature-dependent changes in ligand recognition.

This study demonstrates a portable lab for rapid HBB allele genotyping in field settings, showing feasibility and efficiency in a community-based context.

This study assesses α-α-subunit interactions of Nav1.5 in a heterologous expression system and finds that interactions depend on N-linked glycosylation and non-native disulfide bonds.

This paper uses nanopore long-read sequencing to detect CFTR variants in Moroccan individuals, identifying new pathogenic variants and demonstrating the utility of the method for genetic screening in African populations.

The paper introduces an all-optical Diamond Heater-Thermometer to enable precise thermal modulation of ion channels in living cells.

The paper identifies the binding site of small molecule inhibitors NBA and IBA in TRPM4 using cryo-EM and patch clamp experiments.

This study shows that Trpm4 knockout in mice increases cardiac inflammation and fibrosis after myocardial infarction without improving survival.