3D super-resolution imaging of PSD95 reveals an abundance of diffuse protein supercomplexes in the mouse brain
Sam Daly, Edita Bulovaite, Anoushka Handa, Katie Morris, Leila Mureşan, Candace T. Adams, Takeshi Kaizuka, Alexandre Kitching, Alexander Spark, Gregory J. Chant, Kevin O’Holleran, Seth G. N. Grant, Mathew H. Horrocks, Steven F. Lee
This study uses 3D super-resolution microscopy to analyze PSD95 nanoarchitecture in the mouse brain, revealing diffuse supercomplexes outside synapses and distinct subtypes within synapses.
ACS Chemical Neuroscience · Dec 20, 2024Peer-reviewedBiophysics