Sam Daly

Volumetric single-molecule tracking inside subcellular structures

This paper introduces a method combining single-molecule light-field microscopy with widefield Fourier light-field microscopy to improve volumetric subcellular imaging and molecular diffusion analysis.

Protein-protein interactions drive differences in the spatiotemporal dynamics of transcription factors NANOG and SOX2 in naïve pluripotent cells

The paper tracks SOX2 and NANOG dynamics in live cells using advanced microscopy and analysis pipelines, revealing differences in their spatiotemporal behavior due to protein-protein interactions.

SMOLM-LFM: ratiometric single molecule orientation without polarizers

This paper introduces SMOLM-LFM, a method for 3D single-molecule orientation and localization microscopy using ratiometric intensity estimation without polarization projections, enabling 6D molecular analysis.

3D super-resolution imaging of PSD95 reveals an abundance of diffuse protein supercomplexes in the mouse brain

This study uses 3D super-resolution microscopy to analyze PSD95 nanoarchitecture in the mouse brain, revealing diffuse supercomplexes outside synapses and distinct subtypes within synapses.

Vortex light field microscopy: 3D spectral single-molecule imaging with a twist

This paper introduces vortex light field microscopy, achieving 3D spectral single-molecule imaging with 25 nm spatial and 3 nm spectral precision.