Author

Lukas Perkhofer

University Hospital UlmORCID 0000-0003-0484-0974Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:multiome· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Alexander KlegeriD· 2 shared Alica K. Beutel· 2 shared Dharini SrinivasaniD· 2 shared Eleni ZimmeriD· 2 shared Élodie RogeriD· 2 shared Johann GoutiD· 2 shared M Hänle· 2 shared Albrecht StenzingeriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCancer Biology

Alexander KlegerORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 16, 2025

Exploiting TGF-β-mediated Stromal Programming in Homologous Recombination-Deficient Pancreatic Cancer

Élodie Roger, Hannah M Mummey, Eleni Zimmer…·Alexander Kleger

This study shows that ATM-deficient pancreatic cancers reprogram the tumor microenvironment via TGF-β-driven myCAF enrichment, and targeting this stromal axis with chemotherapy improves therapeutic efficacy.

DOI 10.1101/2025.09.16.676458

mousehuman

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Cancer BiologybioRxivPreprintApr 24, 2025

Pancreatic cancer patient-derived organoids capture therapy response and tumor evolution

Johann Gout, Lukas Perkhofer, Jessica Lindenmayer…·Alexander Kleger

This study uses patient-derived organoids to predict drug response and track tumor evolution in pancreatic cancer.

2 citations

humanorganoid / primary culture

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