Fernanda C. Dos Santos

Investigating the Causal Relationship between Neuroticism and Alzheimer's Disease Using Mendelian Randomization and the Mediating Role of Modifiable Risk Factors

This study uses Mendelian randomization and mediation analysis to show that neuroticism's link to Alzheimer's disease is mediated by modifiable factors like depression, hypertension, and alcohol consumption, rather than being causal.

Distinct Neurodevelopmental Signatures of Sex-Specific Transcriptome-Based Polygenic Risk Scores for Depression

The paper develops sex-specific transcriptome-based polygenic risk scores for depression and evaluates their associations with brain structure and symptoms in adolescents.

Neurostructural and cognitive signatures of novel polygenic risk scores for molecular brain aging

The paper develops polygenic risk scores for molecular brain aging and links them to cortical thickness and cognitive performance in older adults.

Novel polygenic risk score links depression-related cortical transcriptomic changes to brain morphology and symptom severity

This paper develops a transcriptome-based polygenic risk score (T-PRS) linking depression-related cortical gene expression changes to brain morphology and symptom severity in MDD.

Genetic overlap between major depression, bipolar disorder and Alzheimer's Disease

The paper investigates genetic overlap between major depression, bipolar disorder, and Alzheimer's disease using GWAS data and identifies shared genetic correlations and pleiotropic genes.

Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms

The paper develops a transcriptome-based polygenic risk score (T-PRS) linking depression-related gene expression changes to neural face processing and anhedonia in a non-clinical sample.