Michael J. Stam

The paper analyzes a crowdsourced protein design competition, showing participants designed EGFR binders with varying affinities and highlighting challenges in benchmarking and experimental design.

The paper introduces the Protein Design Archive (PDA), a database of designed proteins, and analyzes its contents to show increasing complexity and diversity in protein design over time.

The paper uses predicted protein structures to identify features linked to in vivo behaviour, showing they can predict protein production and recapitulate the tree of life.

DE-STRESS evaluates structural models of designed proteins to identify potential failures early in the design process, providing metrics to guide experimental validation.