Christopher W. Wood

This study shows that the KKT2 CL domain binds histone H3 N-terminus and that methylation of this region disrupts binding, suggesting a mechanism for kinetochore assembly in kinetoplastids.

This paper introduces a fragment-based representation for proteins that improves functional clustering and search efficiency compared to traditional methods.

drFrankenstein automates the generation of AMBER force field parameters for non-canonical amino acids, improving the efficiency and accuracy of molecular dynamics simulations.

This study shows that adding cysteine residues to FAP improves its photostability by quenching harmful triplet states of the FAD cofactor.

The paper analyzes a crowdsourced protein design competition, showing participants designed EGFR binders with varying affinities and highlighting challenges in benchmarking and experimental design.

The paper introduces the Protein Design Archive (PDA), a database of designed proteins, and analyzes its contents to show increasing complexity and diversity in protein design over time.

drMD is an automated pipeline for running molecular dynamics simulations, designed to reduce the expertise required and improve accessibility for non-experts.

The paper designs periplasmic binding protein biosensors using molecular dynamics and residue contact analysis, identifying both known and novel insertion sites for effector proteins.

The paper uses predicted protein structures to identify features linked to in vivo behaviour, showing they can predict protein production and recapitulate the tree of life.

This paper develops photocaged nanobodies for in vivo applications using genetic code expansion and computational methods to control protein interactions with light.

This paper designs peptides that self-assemble into nanoparticles or sheets based on disulfide bond placement, using computational modeling and microscopy.

DE-STRESS evaluates structural models of designed proteins to identify potential failures early in the design process, providing metrics to guide experimental validation.